In silico ADME , BIOACTIVITY SELECTED

Malaria, one of the most widespread diseases, is caused by a plasmodium parasite million people each year, results in several million deaths annually. protozoa that cause malaria, no one antimalarial drug is effective against all four species. research investigation, we performed antimalarial agents. To design a new molecule having good pha information. Key-words: TPSA, GPCR, ADMETox, Malaria is one of the major life bites of infected female Anopheles countries and nearly 3.2 billion people were at risk of malaria. M population increases day by day. This has become major public health burden mortality rate. Malaria in human is caused by six different Plasmodium, which are P. falciparum brasilianum . Its original treatment was quinine first generation of synthetic antimalarial agents. There are four possible sites for drug therapy 1. Kill the sporozoites injected by the mosquito and/ or prevent the sporozoites from entering the liver. 2. Kill the schizonts residing in hepatocytes and/ or prevent them from becoming merozoites. 3. Kill the merozoites in the blood and/ or prev 4. Kill the gametocytes before they can enter the mosquito and reproduce into zygotes. Some argued that the focus at this stage should be block on the male gametocytes. This would block the female gametocytes from mating www.ijapbr.com nd Biological Research, 2016;1(5 Research Article ISSN 1 AND TOXICITY ANALYSIS ANTIMALARIAL AGENTS 2, Chandra Shekhar Sharma Hamendra Pratap Singh2 Udaipur 313001, India and it infects several hundred Because there are four different species of In-silico pharmacokinetic, bioactivity and toxicity rmacological profile, this study